49221 is zip code located in Adrian, Michigan. The population is 42,267, making 49221 the largest zipcode in Adrian and the largest in Lenawee County.
There are 20 public schools in 49221 with an average Homefacts rating of B. The total crime rate for Adrian is moderate , and there are 174 registered sex offenders residing in the zip code 49221. Unemployment in 49221 is moderate.